B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation.

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B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation

Human T hybridomas secreting B cell growth factors (BCGF) and B cell differentiation factor (BCDF) have been established. Hybrid clones 77-A, 94-C, and 98-F secreted BCGF that induced proliferation of anti-IgM-stimulated normal B cells. The culture supernatant from 77-A cells could also maintain continuous proliferation of colony-forming B cells, but the factor from 94-C could not. The addition...

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Distinct Kinds of B Cell Growth Fac tor and Thei r Synergism in B Cell Proliferation

Discovery and use o f T cell growth factor, interleukin 2 (IL-2), 1 have made it possible to immortalize functioning T cells and have facilitated studies on the activation, function, and antigen recognition of T cells (1-3). Human and murine neoplastic T cells secreting IL-2 have been particulary useful for the isolation and molecular characterization of IL-2 (4, 5). Recent studies with success...

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The importance of murine monokines and lymphokines in T cell immune responses has been emphasized by the development o f T cell cloning technology (1) and the identification of cloned tumor lines that respond to or secrete these factors (2, 3). Such studies have shown that the monokine interleukin 1 (IL-1) 1 induces certain T cells to secrete interleukin 2 (IL-2), and that this lymphokine can m...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1983

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.157.2.583